Lab Trainings & Events

This practical toxicological course will provide an introduction to the recent regulatory schemes for the integration of the results of in silico methods and read across. The focus will be on the evaluation of ingredients of cosmetic products. Thanks to the results of a large project funded by a number of cosmetic companies engaged in the field of 3Rs, the course guide you through some schemes to evaluate the substances using non-testing methods. Practical case studies will indicate examples for the assessment of specific endpoints, such as mutagenicity skin sensitization.

Biopredic this year will host its session in the Paris area, at Paul Brousse hospital. Our host there will be the Cellspace society which mission is to develop the bioprinting technologies in the field of regenerative medecine. The lineup of speakers and providers will include scientists involved in the 2D and 3D printing or fabrication of hepatic cell systems. The cell bricks are the hepatocytes, the primary and the HepaRG, and all cells ftom the non parenchymal fraction. A large part of the session will be devoted to the applications of those systems and will cover pbpk modeling, the fm estimation, the low clearance compounds, the genotox and cholestasis prediction.

LIVe2018 intends to be a unique exchange platform for scientists interested in in vitro respiratory researches, stakeholders from academia, pharma, biotech, chemical, tobacco, consumer goods, medical devices industries, CROs and regulatory agencies.
The meeting focuses on predictive in vitro lung models designed for basic research, efficacy and toxicity testing. It aims to present the state-of-art of in vitro lung models, and to map out the route for its future development and use.

Event venue : NOVOTEL Vieux-Nice, 8-10 Esplanade du Parvis de l’Europe, Nice – France

Physiology-based (pharmaco)kinetic PB(P)K modelling has become a promising tool to predict plasma and/or tissue exposure to xenobiotics based on in vitro disposition data. While physiological parameters that characterize the target population have been largely implemented in several PB(P)K platforms, further consensus building is needed with respect to the quality requirements of in vitro data used for a successful bottom-up modelling approach. Therefore, this workshop will focus on improved integration of in vitro drug disposition assessments with the latest developments in the field of PB(P)K-based prediction. Special attention will also be given to prediction of (tissue) partition coefficients.

This two days hands-on training will cover thess topics:
• iPSC and reprogramming (safeiPS, Romain, JML)
• quality control of genetic stability (integrastem, J Devos)
• fluidigm/NGS (veronique Pantesco, seqone)
• 3D printing, bioink (Gilles subra)
• cartilage imaging, preclinical biodistribution after implantation (D Noel, Ecell)

This two-day hands-on training will cover practical use of respiratory in vitro 3D tissues and exposure devices to evaluate acute and repeated dose inhalation toxicity. To mimic systemic context, interconnection strategies of lung tissues will be presented.

At this two days hands-on training, BASF experts will put emphasis on skin sensitization models such as h-clat (OECD TG 442E), DPRA (OECD TG 442C) and LuSens. In comparisons to 2017, this training will focus more intensely on the assessment of the data and testing strategies within the aforementioned models.