After the success of our 1st webinar hosted by the University of Birmingham on “Toxicology by descent” with Prof. John Colbourne, which gathered more than 80 participants, PrecisionTox is delighted to invite you to the next and free “café scientifique” online on the 9th of November from 3-4:30 UK time, with a presentation by Prof. Beate Escher from the Helmholtz Centre for Environmental Research (UFZ) on the topic of “Cell-based bioassays for PrecisionTox … and what else can you do with them?”
Online event via Zoom.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 965406
Cell-based bioassays are at the bottom of the food chain in PrecisionTox but they will hopefully provide relevant information on chemicals’ effects on the cellular level. This webinar will give an introduction to cell-based in vitro assays and how they are used for mechanistic research on cellular toxicity pathways, for the risk assessment of chemicals and in environmental monitoring & biomonitoring. A particular focus will be put on the exposure in cell-based bioassays, introducing tools on how to measure and model the exposure in high-throughput screening assays, which are performed on multi-well plates in small volumes of 20 to 100 µL. A pragmatic experimental workflow to assess stability of test compounds in bioassay media will be presented. A combination of measurements and modeling sheds further light on the exposure, which will help to interpret the results and set the detected effects in context of baseline toxicity.
Prof. Beat Escher bio:
Beate Escher is Head of Department of Cell Toxicology at the Helmholtz Centre for Environmental Research in Leipzig, Germany and Professor at the Eberhard Karls University Tübingen, Germany. She is also lecturer at the Swiss Federal Institute of Technology in ETHZ, Switzerland, holds an honorary professorship at the University of Queensland and an adjunct professorship at Griffith University, Australia. She was Associate Editor for Environmental Science and Technology from 2012 to 2020 and is member of the Board of Reviewing Editors at Science. In 2013 she won the Australian Water Association AWA National Research Innovation Award for her work on cell-based bioassays in water quality assessment. Escher’s research focuses on developing scientifically sound in vitro tools and methodologies for risk assessment of micropollutants in the environment and in people. Escher’s expertise includes the development of in vitro bioassays and applications of new approach methods for monitoring and mode-of-action based effect assessment of organic micropollutants including pharmaceuticals, pesticides and persistent organic pollutants, environmental transformation products, and mixtures. She works towards improving dosing and interpretation of high-throughput in vitro bioassays and developed the robotic bioassay platform CITEPro at UFZ (www.ufz.de/citepro). More practically oriented aspects include passive sampling of sediment, biota and human tissue and effect-based methods for water quality assessment, covering a wide range of different water types from wastewater to drinking water and treatment processes including biological treatment, filtration and advanced oxidation processes, as well as applications of in vitro tools for biomonitoring in fish, mammals and human tissues